One PhD position in the Marie-Curie Initial Training Network "INNOTARGETS": Modelling the metabolism of S. aureus in conjugation with the host
Background
The aim of INNOTARGETS is to train a new generation of early stage researchers (ESRs) in highly innovative approaches to identify metabolic drug targets in pathogenic bacteria, withtechnical skills which are attractive to both industry and academia. In addition to state of the approaches to target identification, they will be equipped with complementary skills deemed important for research team leaders. Each ESR will have an individual profile according to his/her own career dream, and they will be capable of life-long self-directed learning. Twelve ESRs will work closely together in the INNOTARGETS network solving scientific questions related to metabolism of bacteria in the host, mathematical modelling for target identification and toxicity prediction, adaptation of resistant bacteria to treatment, spread of resistance and improved methods for target identification.
Opportunities for one Early Stage Researcher
The Institute of Quantitative and Theoretical Biology at the Heinrich-Heine University Düsseldorf is seeking outstanding candidates for one Early Stage Researcher (ESR).
The successful candidate will develop a genome-scale metabolic model of Staphylococcus aureus. The basis for model development will be more than 50 fully sequenced and published genomes. The model will be interrogated with constraint-based techniques, such as Flux Balance Analysis (FBA), to answer relevant medical questions. These include the prediction of putative targets how metabolism of S. aureus can be interrupted without affecting the human host cells, for which reason the metabolism of host cells will also be considered. Moreover, available expression data will be integrated into the model to assess how metabolic activities change during the course of infection, and how it differs between different S. aureus clones. As part of the project, the student will carry out research at University of Copenhagen to validate model predictions, and he/she will further participate in development of in situ toxicity-prediction-tools during a visit to the pharmaceutical company, ABAC, Barcelona, Spain. The ESR will also participate in network-wide training activities.
Your profile
- MSc in Systems Biology, Bioinformatics, Physics, or any other natural science
- Strong mathematical skills
- A keen interest in biology and medicine
- Curiosity and open-mindedness
- Ability to work individually as well as a member of a team
We offer
- A motivated international team working at cutting-edge research questions in quantitative and theoretical biology
- A pleasant and constructive working environment
- An attractive salary
- Numerous local and international collaborators
- The ideal environment to follow your curiosity and perform excellent research
Mobility rule by the EU
For ITNs, successful candidates must fulfil the mobility criteria defined by the European Commission:
At the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to the reference date.
Specifically, for the ESRs to be recruited at the Heinrich-Heine University, this means that they cannot have lived/worked for more than 12 months in Germany during the 3 years prior to the recruitment date.
We wish to recruit as soon as possible.
Interested candidates please contact Oliver Ebenhöh
There are currently no other open positions @ QTB.
However, the situation may change in the future. People interested in working with us are invited any time to contact us and send motivation letters and CVs.
We also support candidates who wish to acquire their own funding.
